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8,200 words — headwords with part of speech, pronunciation, and a plain-language definition.

en primera instancia: above all, first of all
en primicia: exclusively
en principio: in principle, in theory
en privado: privately, in private
en pro de: on behalf of; in the name of, for the sake of
en profundidad: deeply; profoundly; in great detail
en prueba de: as a test of; in proof of; in order to show
en publicidad: publicly
en puertas: coming up; around the corner
en punta: en pointe
en puntillas: on tiptoe
en punto: o'clock; on the dot, sharp
en público: in public
en qué quedamos: what's it to be? what'll it be?
en razón a: synonym of en razón de
en razón de: when it comes to; regarding; due to; as a result of; in line with; in accordance with
en realidad: actually; in reality
en realidad de verdad: in truth; truthfully
en rebeldía: in absentia
en redondo: flatly; outright
en redor: nearby
en regla: in working order, correctly
en relación con: related to; connected to; as for; when it comes to
en renta: rented; in a rental
en resumen: in summary, in sum; long story short
en resumidas cuentas: to sum up, in sum
en ridículo: ridiculized
en rigor: in truth; in reality
en ristre: at the ready
en ropas menores: in one's underwear
en salvo: freely
en sazón: ripe
en seco: abruptly; dry (without water, by drycleaning)
en secreto: in secret, secretly
en seguida: alternative spelling of enseguida
en sentido antihorario: anticlockwise (South Africa, AU, New Zealand, Britain), counterclockwise (US) (in an anticlockwise fashion)
en sentido contrario a las agujas del reloj: anticlockwise (South Africa, AU, New Zealand, Britain), counterclockwise (US) (in an anticlockwise fashion)
en sentido horario: clockwise
en serie: serial; in series
en serio: seriously, really, for real, in earnest, on the level
en silencio: silently, in silence, quietly, wordlessly, mutely; on mute (for an electronic device that sounds)
en silencio: silent
en singular: especially; singularly
en situación de calle: homeless (lacking a permanent residence)
en solitario: solo; unaccompanied
en solitario: solo; alone; by oneself
en son de: in; as (in a certain way)
en sordina: hushedly, quietly
en su defecto: in its abscence; if [something/someone] is missing; failing this
en su fuero interno: deep down; in one's heart of hearts
en su justa medida: for its true worth
en su mayoría: mostly, for the most part
en su momento: when time is ripe; at that moment, back then
en su punto: just perfect; fine and dandy
en su punto: just perfectly
en su salsa: in one's element
en su sano juicio: in one's right mind
en su vida: never; ever; never ever
en sueños: in one's dreams
en suma: on the whole, all in all