autodestruirse

Both literal (a device programmed to destroy itself) and figurative (a person or relationship ruining itself through its own actions) — the figurative sense is extremely common in everyday and pop-culture Spanish.

• El robot se autodestruye si detecta manipulación no autorizada. — The robot self-destructs if it detects unauthorized tampering.
• Su carrera se autodestruyó por decisiones impulsivas. — His career self-destructed because of impulsive decisions.
• Dejó de beber antes de autodestruirse por completo. — He stopped drinking before completely destroying himself.

In the figurative sense, learners often reach for destruirse a sí mismo, which is grammatically fine but sounds clunkier — autodestruirse is the natural single-word choice native speakers use.

• quote "Este mensaje se autodestruirá en cinco segundos" — The Spanish-dub catchphrase from the Mission: Impossible TV series (1966–1973) and its later film franchise — the recorded briefing line preceding each mission, one of the most recognized lines from the franchise in Spanish-speaking markets.